Improvement of Biophysical Properties and Affinity of a Human Anti-L1CAM Therapeutic Antibody through Antibody Engineering Based on Computational Methods

The biophysical properties of therapeutic antibodies influence their manufacturability, efficacy, and safety. To develop an anti-cancer antibody, we previously generated a human monoclonal antibody (Ab417) that specifically binds to L1 cell adhesion molecule with a high affinity, and we validated it...

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Detalles Bibliográficos
Autores principales: Chae, Heesu, Cho, Seulki, Jeong, Munsik, Kwon, Kiyoung, Choi, Dongwook, Lee, Jaeyoung, Nam, Woosuk, Hong, Jisu, Lee, Jiwoo, Yoon, Seonjoo, Hong, Hyojeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268072/
https://www.ncbi.nlm.nih.gov/pubmed/34206616
http://dx.doi.org/10.3390/ijms22136696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268072/
https://www.ncbi.nlm.nih.gov/pubmed/34206616
http://dx.doi.org/10.3390/ijms22136696

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