The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo

Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson’s disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understood. We previously showed that the C-terminal portion o...

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Detalles Bibliográficos
Autores principales: Cresto, Noémie, Gardier, Camille, Gaillard, Marie-Claude, Gubinelli, Francesco, Roost, Pauline, Molina, Daniela, Josephine, Charlène, Dufour, Noëlle, Auregan, Gwenaëlle, Guillermier, Martine, Bernier, Suéva, Jan, Caroline, Gipchtein, Pauline, Hantraye, Philippe, Chartier-Harlin, Marie-Christine, Bonvento, Gilles, Van Camp, Nadja, Taymans, Jean-Marc, Cambon, Karine, Liot, Géraldine, Bemelmans, Alexis-Pierre, Brouillet, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268201/
https://www.ncbi.nlm.nih.gov/pubmed/34201785
http://dx.doi.org/10.3390/ijms22136760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268201/
https://www.ncbi.nlm.nih.gov/pubmed/34201785
http://dx.doi.org/10.3390/ijms22136760

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