The Glucosylceramide Synthase Inhibitor PDMP Causes Lysosomal Lipid Accumulation and mTOR Inactivation

For many years, the biology of glycosphingolipids was elucidated with the help of glucosylceramide synthase (GCS) inhibitors such as 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP). Additionally, PDMP gained interest because of its chemosensitizing effects. Several studies have successfully...

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Detalles Bibliográficos
Autores principales: Hartwig, Pia, Höglinger, Doris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268262/
https://www.ncbi.nlm.nih.gov/pubmed/34209164
http://dx.doi.org/10.3390/ijms22137065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268262/
https://www.ncbi.nlm.nih.gov/pubmed/34209164
http://dx.doi.org/10.3390/ijms22137065

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