Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis

SIMPLE SUMMARY: Cancers often loose the enzyme of folate metabolism ALDH1L1. We proposed that such loss is advantageous for the malignant tumor growth and tested this hypothesis in mice proficient or deficient (gene knockout) in ALDH1L1 expression. Liver cancer in both groups was induced by injectio...

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Detalles Bibliográficos
Autores principales: Krupenko, Natalia I., Sharma, Jaspreet, Fogle, Halle M., Pediaditakis, Peter, Strickland, Kyle C., Du, Xiuxia, Helke, Kristi L., Sumner, Susan, Krupenko, Sergey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268287/
https://www.ncbi.nlm.nih.gov/pubmed/34203215
http://dx.doi.org/10.3390/cancers13133219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268287/
https://www.ncbi.nlm.nih.gov/pubmed/34203215
http://dx.doi.org/10.3390/cancers13133219

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