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Aη-α and Aη-β peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo
BACKGROUND: Amyloid precursor protein (APP) processing is central to Alzheimer’s disease (AD) etiology. As early cognitive alterations in AD are strongly correlated to abnormal information processing due to increasing synaptic impairment, it is crucial to characterize how peptides generated through...
Autores principales: | Mensch, Maria, Dunot, Jade, Yishan, Sandy M., Harris, Samuel S., Blistein, Aline, Avdiu, Alban, Pousinha, Paula A., Giudici, Camilla, Busche, Marc Aurel, Jedlicka, Peter, Willem, Michael, Marie, Hélène |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268417/ https://www.ncbi.nlm.nih.gov/pubmed/34238366 http://dx.doi.org/10.1186/s13195-021-00860-1 |
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