Image-Based In Vitro Screening Reveals the Trypanostatic Activity of Hydroxymethylnitrofurazone against Trypanosoma cruzi

Hydroxymethylnitrofurazone (NFOH) is a therapeutic candidate for Chagas disease (CD). It has negligible hepatotoxicity in a murine model compared to the front-line drug benznidazole (BZN). Here, using Trypanosoma cruzi strains that express bioluminescent and/or fluorescent reporter proteins, we furt...

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Detalles Bibliográficos
Autores principales: Scarim, Cauê Benito, Olmo, Francisco, Ferreira, Elizabeth Igne, Chin, Chung Man, Kelly, John M., Fortes Francisco, Amanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268475/
https://www.ncbi.nlm.nih.gov/pubmed/34203228
http://dx.doi.org/10.3390/ijms22136930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268475/
https://www.ncbi.nlm.nih.gov/pubmed/34203228
http://dx.doi.org/10.3390/ijms22136930

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