The Adipose Tissue-Derived Secretome (ADS) in Obesity Uniquely Induces L-Type Amino Acid Transporter 1 (LAT1) and mTOR Signaling in Estrogen-Receptor-Positive Breast Cancer Cells

Obesity increases the risk of postmenopausal breast cancer (BC). This risk is mediated by obesity-induced changes in the adipose-derived secretome (ADS). The pathogenesis of BC in obesity is stimulated by mTOR hyperactivity. In obesity, leucine might support mTOR hyperactivity. Leucine uptake by BC...

Descripción completa

Detalles Bibliográficos
Autores principales: Thompson, Chelsea, Rahman, M Motiur, Singh, Soudamani, Arthur, Subha, Sierra-Bakhshi, Cecilia, Russell, Rebecca, Denning, Krista, Sundaram, Uma, Salisbury, Travis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268498/
https://www.ncbi.nlm.nih.gov/pubmed/34201429
http://dx.doi.org/10.3390/ijms22136706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268498/
https://www.ncbi.nlm.nih.gov/pubmed/34201429
http://dx.doi.org/10.3390/ijms22136706

Ejemplares similares