The Adipose Tissue-Derived Secretome (ADS) in Obesity Uniquely Induces L-Type Amino Acid Transporter 1 (LAT1) and mTOR Signaling in Estrogen-Receptor-Positive Breast Cancer Cells

Obesity increases the risk of postmenopausal breast cancer (BC). This risk is mediated by obesity-induced changes in the adipose-derived secretome (ADS). The pathogenesis of BC in obesity is stimulated by mTOR hyperactivity. In obesity, leucine might support mTOR hyperactivity. Leucine uptake by BC...

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Detalles Bibliográficos
Autores principales: Thompson, Chelsea, Rahman, M Motiur, Singh, Soudamani, Arthur, Subha, Sierra-Bakhshi, Cecilia, Russell, Rebecca, Denning, Krista, Sundaram, Uma, Salisbury, Travis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268498/
https://www.ncbi.nlm.nih.gov/pubmed/34201429
http://dx.doi.org/10.3390/ijms22136706

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