A review of mechanisms of disease across PIK3CA-related disorders with vascular manifestations

BACKGROUND: PIK3CA-related disorders include vascular malformations and overgrowth of various tissues that are caused by postzygotic, somatic variants in the gene encoding phosphatidylinositol-3-kinase (PI3K) catalytic subunit alpha. These mutations result in activation of the PI3K/AKT/mTOR signalin...

Descripción completa

Detalles Bibliográficos
Autores principales: Canaud, Guillaume, Hammill, Adrienne M., Adams, Denise, Vikkula, Miikka, Keppler-Noreuil, Kim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268514/
https://www.ncbi.nlm.nih.gov/pubmed/34238334
http://dx.doi.org/10.1186/s13023-021-01929-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268514/
https://www.ncbi.nlm.nih.gov/pubmed/34238334
http://dx.doi.org/10.1186/s13023-021-01929-8

Ejemplares similares