MM-129 as a Novel Inhibitor Targeting PI3K/AKT/mTOR and PD-L1 in Colorectal Cancer

SIMPLE SUMMARY: MM-129 (1,2,4-triazine derivative) is a novel promising drug candidate against colon cancer. It has the ability to inhibit intracellular pathways promoting tumorigenesis with a simultaneous reduction of PD-L1 expression, a key element of the cancer immune escape axis. MM-129 may also...

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Detalles Bibliográficos
Autores principales: Hermanowicz, Justyna Magdalena, Pawlak, Krystyna, Sieklucka, Beata, Czarnomysy, Robert, Kwiatkowska, Iwona, Kazberuk, Adam, Surazynski, Arkadiusz, Mojzych, Mariusz, Pawlak, Dariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268553/
https://www.ncbi.nlm.nih.gov/pubmed/34206937
http://dx.doi.org/10.3390/cancers13133203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268553/
https://www.ncbi.nlm.nih.gov/pubmed/34206937
http://dx.doi.org/10.3390/cancers13133203

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