Organoprotective Effects of Spironolactone on Top of Ramipril Therapy in a Mouse Model for Alport Syndrome

Angiotensin-converting enzyme inhibitors (ACEi) delay progression of the inherited renal disease Alport syndrome. However, the effect of ACEis weakens gradually due to an “aldosterone escape”. Here, we investigate if an aldosterone antagonist can counteract loss of ACEi-efficacy. COL4A3−/− mice were...

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Detalles Bibliográficos
Autores principales: Rubel, Diana, Zhang, Yanqin, Sowa, Nenja, Girgert, Rainer, Gross, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268845/
https://www.ncbi.nlm.nih.gov/pubmed/34209341
http://dx.doi.org/10.3390/jcm10132958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268845/
https://www.ncbi.nlm.nih.gov/pubmed/34209341
http://dx.doi.org/10.3390/jcm10132958

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