Cytosolic 5′-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway

Cytosolic 5′-nucleotidase II (cN-II) is an allosteric catabolic enzyme that hydrolyzes IMP, GMP, and AMP. The enzyme can assume at least two different structures, being the more active conformation stabilized by ATP and the less active by inorganic phosphate. Therefore, the variation in ATP concentr...

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Detalles Bibliográficos
Autores principales: Pesi, Rossana, Allegrini, Simone, Garcia-Gil, Mercedes, Piazza, Lucia, Moschini, Roberta, Jordheim, Lars Petter, Camici, Marcella, Tozzi, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268954/
https://www.ncbi.nlm.nih.gov/pubmed/34209768
http://dx.doi.org/10.3390/ijms22137004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268954/
https://www.ncbi.nlm.nih.gov/pubmed/34209768
http://dx.doi.org/10.3390/ijms22137004

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