Identification of 13 Guanidinobenzoyl- or Aminidinobenzoyl-Containing Drugs to Potentially Inhibit TMPRSS2 for COVID-19 Treatment

Positively charged groups that mimic arginine or lysine in a natural substrate of trypsin are necessary for drugs to inhibit the trypsin-like serine protease TMPRSS2 that is involved in the viral entry and spread of coronaviruses, including SARS-CoV-2. Based on this assumption, we identified a set o...

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Detalles Bibliográficos
Autores principales: Huang, Xiaoqiang, Pearce, Robin, Omenn, Gilbert S., Zhang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269196/
https://www.ncbi.nlm.nih.gov/pubmed/34209110
http://dx.doi.org/10.3390/ijms22137060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269196/
https://www.ncbi.nlm.nih.gov/pubmed/34209110
http://dx.doi.org/10.3390/ijms22137060

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