Cargando…

Genomic Determinants Encode the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes

Halogenases create diverse natural products by utilizing halide ions and are of great interest in the synthesis of potential pharmaceuticals and agrochemicals. An increasing number of halogenases discovered in microorganisms are annotated as flavin-dependent halogenases (FDHs), but their chemical re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeon, Jehyun, Lee, Jaehee, Jung, Se-Min, Shin, Jae Hong, Song, Woon Ju, Rho, Mina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269204/ https://www.ncbi.nlm.nih.gov/pubmed/34042468 http://dx.doi.org/10.1128/mSystems.00053-21

Ejemplares similares

Structural basis of regioselective tryptophan dibromination by the single-component flavin-dependent halogenase AetF
por: Gäfe, Simon, et al.
Publicado: (2023)

Mechanism of Action of Flavin-Dependent Halogenases
por: Barker, Rhys D., et al.
Publicado: (2022)

A flavin-dependent halogenase from metagenomic analysis prefers bromination over chlorination
por: Neubauer, Pia R., et al.
Publicado: (2018)

Halogenase‐Inspired Oxidative Chlorination Using Flavin Photocatalysis
por: Hering, Thea, et al.
Publicado: (2016)

Dissecting the low catalytic capability of flavin-dependent halogenases
por: Phintha, Aisaraphon, et al.
Publicado: (2020)

Flavin-dependent halogenases catalyze enantioselective olefin halocyclization
por: Mondal, Dibyendu, et al.
Publicado: (2021)

Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes
por: Shepherd, Sarah A., et al.
Publicado: (2015)

Predicting the Substrate Scope of the Flavin‐Dependent Halogenase BrvH
por: Neubauer, Pia R., et al.
Publicado: (2020)

A Structure‐Guided Switch in the Regioselectivity of a Tryptophan Halogenase
por: Shepherd, Sarah A., et al.
Publicado: (2016)

Crystallographic and thermodynamic evidence of negative cooperativity of flavin and tryptophan binding in the flavin-dependent halogenases AbeH and BorH
por: Ashaduzzaman, Md, et al.
Publicado: (2023)

The Single‐Component Flavin Reductase/Flavin‐Dependent Halogenase AetF is a Versatile Catalyst for Selective Bromination and Iodination of Arenes and Olefins
por: Jiang, Yuhua, et al.
Publicado: (2022)

Metagenomic characterization of sphingomyelinase C in the microbiome of humans and environments
por: Jeon, Jehyun, et al.
Publicado: (2022)

Structure of apo flavin-dependent halogenase Xcc4156 hints at a reason for cofactor-soaking difficulties
por: Widmann, Christiane, et al.
Publicado: (2020)

Site-Selective C–H Halogenation Using Flavin-Dependent Halogenases Identified via Family-Wide Activity Profiling
por: Fisher, Brian F., et al.
Publicado: (2019)

Regioselective para‐Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase
por: Payer, Stefan E., et al.
Publicado: (2017)

Does Substrate Positioning Affect the Selectivity and Reactivity in the Hectochlorin Biosynthesis Halogenase?
por: Timmins, Amy, et al.
Publicado: (2018)

Structural Insights from Molecular Dynamics Simulations of Tryptophan 7-Halogenase and Tryptophan 5-Halogenase
por: Ainsley, Jon, et al.
Publicado: (2018)

A Promiscuous Halogenase for the Derivatization of Flavonoids
por: Kolling, Dominik, et al.
Publicado: (2021)

Integrative metagenomic and biochemical studies on rifamycin ADP-ribosyltransferases discovered in the sediment microbiome
por: Shin, Jae Hong, et al.
Publicado: (2018)

Electrostatically regulated active site assembly governs reactivity in non-heme iron halogenases
por: Smithwick, Elizabeth R., et al.
Publicado: (2023)

Culture-dependent and independent approaches for identifying novel halogenases encoded by Crambe crambe (marine sponge) microbiota
por: Öztürk, Başak, et al.
Publicado: (2013)

Diversity of tryptophan halogenases in sponges of the genus Aplysina
por: Gutleben, Johanna, et al.
Publicado: (2019)

Distribution and diversity of dimetal-carboxylate halogenases in cyanobacteria
por: Eusebio, Nadia, et al.
Publicado: (2021)

Bioprospecting potential of halogenases from Arctic marine actinomycetes
por: Liao, Li, et al.
Publicado: (2016)

A Marine Viral Halogenase that Iodinates Diverse Substrates
por: Gkotsi, Danai S., et al.
Publicado: (2019)

Halogenase-Targeted Genome Mining Leads to the Discovery of (±) Pestalachlorides A1a, A2a, and Their Atropisomers
por: Luo, Mengna, et al.
Publicado: (2022)

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase
por: Matthews, Megan L, et al.
Publicado: (2014)

RadH: A Versatile Halogenase for Integration into Synthetic Pathways
por: Menon, Binuraj R. K., et al.
Publicado: (2017)

Unusual substrate and halide versatility of phenolic halogenase PltM
por: Mori, Shogo, et al.
Publicado: (2019)

Halogenation of Peptides and Proteins Using Engineered Tryptophan Halogenase Enzymes
por: Sana, Barindra, et al.
Publicado: (2022)

Further Characterization of Fungal Halogenase RadH and Its Homologs
por: Peh, GuangRong, et al.
Publicado: (2023)

Broadening the Scope of the Flavin‐Tag Method by Improving Flavin Incorporation and Incorporating Flavin Analogs
por: Tong, Yapei, et al.
Publicado: (2022)

Unusual reactivity of a flavin in a bifurcating electron-transferring flavoprotein leads to flavin modification and a charge-transfer complex
por: Mohamed-Raseek, Nishya, et al.
Publicado: (2022)

Mechanistic Insights into the Reaction of Chlorination of Tryptophan Catalyzed by Tryptophan 7-Halogenase
por: Karabencheva-Christova, Tatyana G., et al.
Publicado: (2017)

Binding of FAD and tryptophan to the tryptophan 6‐halogenase Thal is negatively coupled
por: Moritzer, Ann‐Christin, et al.
Publicado: (2019)

Noncovalent interactions that tune the reactivities of the flavins in bifurcating electron transferring flavoprotein
por: González-Viegas, María, et al.
Publicado: (2023)

Reconstruction of Bacterial and Viral Genomes from Multiple Metagenomes
por: Gupta, Ankit, et al.
Publicado: (2016)

Identification and classification of reverse transcriptases in bacterial genomes and metagenomes
por: Sharifi, Fatemeh, et al.
Publicado: (2021)

Publisher Correction: Unusual substrate and halide versatility of phenolic halogenase PltM
por: Mori, Shogo, et al.
Publicado: (2019)

XszenFHal, a novel tryptophan 5-halogenase from Xenorhabdus szentirmaii
por: Domergue, Jérémy, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jsbc8fv5j03poppvs4jjrol7jj