Cargando…

Cohesin Mutations in Cancer: Emerging Therapeutic Targets

The cohesin complex is crucial for mediating sister chromatid cohesion and for hierarchal three-dimensional organization of the genome. Mutations in cohesin genes are present in a range of cancers. Extensive research over the last few years has shown that cohesin mutations are key events that contri...

Descripción completa

Detalles Bibliográficos
Autores principales: Antony, Jisha, Chin, Chue Vin, Horsfield, Julia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269296/
https://www.ncbi.nlm.nih.gov/pubmed/34202641
http://dx.doi.org/10.3390/ijms22136788
_version_ 1783720547329245184
author Antony, Jisha
Chin, Chue Vin
Horsfield, Julia A.
author_facet Antony, Jisha
Chin, Chue Vin
Horsfield, Julia A.
author_sort Antony, Jisha
collection PubMed
description The cohesin complex is crucial for mediating sister chromatid cohesion and for hierarchal three-dimensional organization of the genome. Mutations in cohesin genes are present in a range of cancers. Extensive research over the last few years has shown that cohesin mutations are key events that contribute to neoplastic transformation. Cohesin is involved in a range of cellular processes; therefore, the impact of cohesin mutations in cancer is complex and can be cell context dependent. Candidate targets with therapeutic potential in cohesin mutant cells are emerging from functional studies. Here, we review emerging targets and pharmacological agents that have therapeutic potential in cohesin mutant cells.
format Online
Article
Text
id pubmed-8269296
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82692962021-07-10 Cohesin Mutations in Cancer: Emerging Therapeutic Targets Antony, Jisha Chin, Chue Vin Horsfield, Julia A. Int J Mol Sci Review The cohesin complex is crucial for mediating sister chromatid cohesion and for hierarchal three-dimensional organization of the genome. Mutations in cohesin genes are present in a range of cancers. Extensive research over the last few years has shown that cohesin mutations are key events that contribute to neoplastic transformation. Cohesin is involved in a range of cellular processes; therefore, the impact of cohesin mutations in cancer is complex and can be cell context dependent. Candidate targets with therapeutic potential in cohesin mutant cells are emerging from functional studies. Here, we review emerging targets and pharmacological agents that have therapeutic potential in cohesin mutant cells. MDPI 2021-06-24 /pmc/articles/PMC8269296/ /pubmed/34202641 http://dx.doi.org/10.3390/ijms22136788 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Antony, Jisha
Chin, Chue Vin
Horsfield, Julia A.
Cohesin Mutations in Cancer: Emerging Therapeutic Targets
title Cohesin Mutations in Cancer: Emerging Therapeutic Targets
title_full Cohesin Mutations in Cancer: Emerging Therapeutic Targets
title_fullStr Cohesin Mutations in Cancer: Emerging Therapeutic Targets
title_full_unstemmed Cohesin Mutations in Cancer: Emerging Therapeutic Targets
title_short Cohesin Mutations in Cancer: Emerging Therapeutic Targets
title_sort cohesin mutations in cancer: emerging therapeutic targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269296/
https://www.ncbi.nlm.nih.gov/pubmed/34202641
http://dx.doi.org/10.3390/ijms22136788
work_keys_str_mv AT antonyjisha cohesinmutationsincanceremergingtherapeutictargets
AT chinchuevin cohesinmutationsincanceremergingtherapeutictargets
AT horsfieldjuliaa cohesinmutationsincanceremergingtherapeutictargets