AML-Related NPM Mutations Drive p53 Delocalization into the Cytoplasm with Possible Impact on p53-Dependent Stress Response

SIMPLE SUMMARY: Nucleophosmin (NPM) is one of the most abundant nucleolar proteins and its mutations frequently occur in acute myeloid leukemia (AML). The mutations cause aberrant cytoplasmic localization of mutated protein (NPMmut) and often mediate dislocation of NPM interaction partners. Tumor su...

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Detalles Bibliográficos
Autores principales: Holoubek, Aleš, Strachotová, Dita, Otevřelová, Petra, Röselová, Pavla, Heřman, Petr, Brodská, Barbora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269334/
https://www.ncbi.nlm.nih.gov/pubmed/34209894
http://dx.doi.org/10.3390/cancers13133266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269334/
https://www.ncbi.nlm.nih.gov/pubmed/34209894
http://dx.doi.org/10.3390/cancers13133266

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