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AML-Related NPM Mutations Drive p53 Delocalization into the Cytoplasm with Possible Impact on p53-Dependent Stress Response
SIMPLE SUMMARY: Nucleophosmin (NPM) is one of the most abundant nucleolar proteins and its mutations frequently occur in acute myeloid leukemia (AML). The mutations cause aberrant cytoplasmic localization of mutated protein (NPMmut) and often mediate dislocation of NPM interaction partners. Tumor su...
Autores principales: | Holoubek, Aleš, Strachotová, Dita, Otevřelová, Petra, Röselová, Pavla, Heřman, Petr, Brodská, Barbora |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269334/ https://www.ncbi.nlm.nih.gov/pubmed/34209894 http://dx.doi.org/10.3390/cancers13133266 |
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