Selective Inhibition of Heparan Sulphate and Not Chondroitin Sulphate Biosynthesis by a Small, Soluble Competitive Inhibitor

The glycosaminoglycan, heparan sulphate (HS), orchestrates many developmental processes. Yet its biological role has not yet fully been elucidated. Small molecule chemical inhibitors can be used to perturb HS function and these compounds provide cheap alternatives to genetic manipulation methods. Ho...

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Detalles Bibliográficos
Autores principales: Maciej-Hulme, Marissa L., Dubaissi, Eamon, Shao, Chun, Zaia, Joseph, Amaya, Enrique, Flitsch, Sabine L., Merry, Catherine L. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269443/
https://www.ncbi.nlm.nih.gov/pubmed/34209670
http://dx.doi.org/10.3390/ijms22136988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269443/
https://www.ncbi.nlm.nih.gov/pubmed/34209670
http://dx.doi.org/10.3390/ijms22136988

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