Sonlicromanol’s active metabolite KH176m normalizes prostate cancer stem cell mPGES-1 overexpression and inhibits cancer spheroid growth

Aggressiveness of cancers, like prostate cancer, has been found to be associated with elevated expression of the microsomal prostaglandin E synthase-1 (mPGES-1). Here, we investigated whether KH176m (the active metabolite of sonlicromanol), a recently discovered selective mPGES-1 inhibitor, could af...

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Detalles Bibliográficos
Autores principales: Jiang, Xiaolan, Renkema, Herma, Smeitink, Jan, Beyrath, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270194/
https://www.ncbi.nlm.nih.gov/pubmed/34242345
http://dx.doi.org/10.1371/journal.pone.0254315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270194/
https://www.ncbi.nlm.nih.gov/pubmed/34242345
http://dx.doi.org/10.1371/journal.pone.0254315

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