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An integrative network-based approach for drug target indication expansion
BACKGROUND: The identification of a target-indication pair is regarded as the first step in a traditional drug discovery and development process. Significant investment and attrition occur during discovery and development before a molecule is shown to be safe and efficacious for the selected indicat...
Autores principales: | Han, Yingnan, Wang, Clarence, Klinger, Katherine, Rajpal, Deepak K., Zhu, Cheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270215/ https://www.ncbi.nlm.nih.gov/pubmed/34242265 http://dx.doi.org/10.1371/journal.pone.0253614 |
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