4,7-Disubstituted 7H-Pyrrolo[2,3-d]pyrimidines and Their Analogs as Antiviral Agents against Zika Virus

Discovery of compound 1 as a Zika virus (ZIKV) inhibitor has prompted us to investigate its 7H-pyrrolo[2,3-d]pyrimidine scaffold, revealing structural features that elicit antiviral activity. Furthermore, we have demonstrated that 9H-purine or 1H-pyrazolo[3,4-d]pyrimidine can serve as an alternative...

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Detalles Bibliográficos
Autores principales: Soto-Acosta, Ruben, Jung, Eunkyung, Qiu, Li, Wilson, Daniel J., Geraghty, Robert J., Chen, Liqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270260/
https://www.ncbi.nlm.nih.gov/pubmed/34206327
http://dx.doi.org/10.3390/molecules26133779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270260/
https://www.ncbi.nlm.nih.gov/pubmed/34206327
http://dx.doi.org/10.3390/molecules26133779

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