Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of 15 nm

Prion diseases are transmissible neurodegenerative disorders that affect mammals, including humans. The central molecular event is the conversion of cellular prion glycoprotein, PrP(C), into a plethora of assemblies, PrP(Sc), associated with disease. Distinct phenotypes of disease led to the concept...

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Detalles Bibliográficos
Autores principales: Cortez, Leonardo M., Nemani, Satish K., Duque Velásquez, Camilo, Sriraman, Aishwarya, Wang, YongLiang, Wille, Holger, McKenzie, Debbie, Sim, Valerie L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270404/
https://www.ncbi.nlm.nih.gov/pubmed/34181702
http://dx.doi.org/10.1371/journal.ppat.1009703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270404/
https://www.ncbi.nlm.nih.gov/pubmed/34181702
http://dx.doi.org/10.1371/journal.ppat.1009703

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