Cargando…
Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of 15 nm
Prion diseases are transmissible neurodegenerative disorders that affect mammals, including humans. The central molecular event is the conversion of cellular prion glycoprotein, PrP(C), into a plethora of assemblies, PrP(Sc), associated with disease. Distinct phenotypes of disease led to the concept...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270404/ https://www.ncbi.nlm.nih.gov/pubmed/34181702 http://dx.doi.org/10.1371/journal.ppat.1009703 |