De novo mutational signature discovery in tumor genomes using SparseSignatures

Cancer is the result of mutagenic processes that can be inferred from tumor genomes by analyzing rate spectra of point mutations, or “mutational signatures”. Here we present SparseSignatures, a novel framework to extract signatures from somatic point mutation data. Our approach incorporates a user-s...

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Detalles Bibliográficos
Autores principales: Lal, Avantika, Liu, Keli, Tibshirani, Robert, Sidow, Arend, Ramazzotti, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270462/
https://www.ncbi.nlm.nih.gov/pubmed/34181655
http://dx.doi.org/10.1371/journal.pcbi.1009119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270462/
https://www.ncbi.nlm.nih.gov/pubmed/34181655
http://dx.doi.org/10.1371/journal.pcbi.1009119

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