Loss of UCHL1 rescues the defects related to Parkinson’s disease by suppressing glycolysis

The role of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1; also called PARK5) in the pathogenesis of Parkinson’s disease (PD) has been controversial. Here, we find that the loss of UCHL1 destabilizes pyruvate kinase (PKM) and mitigates the PD-related phenotypes induced by PTEN-induced kinase 1 (PI...

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Detalles Bibliográficos
Autores principales: Ham, Su Jin, Lee, Daewon, Xu, Wen Jun, Cho, Eunjoo, Choi, Sekyu, Min, Soohong, Park, Sunghyouk, Chung, Jongkyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270484/
https://www.ncbi.nlm.nih.gov/pubmed/34244144
http://dx.doi.org/10.1126/sciadv.abg4574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270484/
https://www.ncbi.nlm.nih.gov/pubmed/34244144
http://dx.doi.org/10.1126/sciadv.abg4574

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