Reciprocal interaction between SIRT6 and APC/C regulates genomic stability

SIRT6 is an NAD(+)-dependent deacetylase that plays an important role in mitosis fidelity and genome stability. In the present study, we found that SIRT6 overexpression leads to mitosis defects and aneuploidy. We identified SIRT6 as a novel substrate of anaphase-promoting complex/cyclosome (APC/C),...

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Detalles Bibliográficos
Autores principales: Wang, Helin, Feng, Kangze, Wang, Qingtao, Deng, Haiteng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270898/
https://www.ncbi.nlm.nih.gov/pubmed/34244565
http://dx.doi.org/10.1038/s41598-021-93684-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270898/
https://www.ncbi.nlm.nih.gov/pubmed/34244565
http://dx.doi.org/10.1038/s41598-021-93684-w

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