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Reciprocal interaction between SIRT6 and APC/C regulates genomic stability
SIRT6 is an NAD(+)-dependent deacetylase that plays an important role in mitosis fidelity and genome stability. In the present study, we found that SIRT6 overexpression leads to mitosis defects and aneuploidy. We identified SIRT6 as a novel substrate of anaphase-promoting complex/cyclosome (APC/C),...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270898/ https://www.ncbi.nlm.nih.gov/pubmed/34244565 http://dx.doi.org/10.1038/s41598-021-93684-w |