Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes

Alternative splicing generates differing RNA isoforms that govern phenotypic complexity of eukaryotes. Its malfunction underlies many diseases, including cancer and cardiovascular diseases. Comparative analysis of RNA isoforms at the genome-wide scale has been difficult. Here, we establish an experi...

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Detalles Bibliográficos
Autores principales: Zhu, Chenchen, Wu, Jingyan, Sun, Han, Briganti, Francesca, Meder, Benjamin, Wei, Wu, Steinmetz, Lars M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270901/
https://www.ncbi.nlm.nih.gov/pubmed/34244519
http://dx.doi.org/10.1038/s41467-021-24484-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270901/
https://www.ncbi.nlm.nih.gov/pubmed/34244519
http://dx.doi.org/10.1038/s41467-021-24484-z

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