Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness

Extracellular matrix protein-1 (ECM1) promotes tumorigenesis in multiple organs but the mechanisms associated to ECM1 isoform subtypes have yet to be clarified. We report in this study that the secretory ECM1a isoform induces tumorigenesis through the GPR motif binding to integrin αXβ2 and the activ...

Descripción completa

Detalles Bibliográficos
Autores principales: Yin, Huijing, Wang, Jingshu, Li, Hui, Yu, Yinjue, Wang, Xiaoling, Lu, Lili, Lv, Cuiting, Chang, Bin, Jin, Wei, Guo, Wenwen, Ren, Chunxia, Yang, Gong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270969/
https://www.ncbi.nlm.nih.gov/pubmed/34244494
http://dx.doi.org/10.1038/s41467-021-24315-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270969/
https://www.ncbi.nlm.nih.gov/pubmed/34244494
http://dx.doi.org/10.1038/s41467-021-24315-1

Ejemplares similares