mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis

Glycine decarboxylase (GLDC) is a key enzyme of glycine cleavage system that converts glycine into one-carbon units. GLDC is commonly up-regulated and plays important roles in many human cancers. Whether and how GLDC is regulated by post-translational modifications is unknown. Here we report that me...

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Detalles Bibliográficos
Autores principales: Liu, Rui, Zeng, Lin-Wen, Gong, Rong, Yuan, Fanen, Shu, Hong-Bing, Li, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270999/
https://www.ncbi.nlm.nih.gov/pubmed/34244482
http://dx.doi.org/10.1038/s41467-021-24321-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270999/
https://www.ncbi.nlm.nih.gov/pubmed/34244482
http://dx.doi.org/10.1038/s41467-021-24321-3

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