Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases

Streptococcus pyogenes (Spy) Cas9 has potential as a component of gene therapeutics for incurable diseases. One of its limitations is its large size, which impedes its formulation and delivery in therapeutic applications. Smaller Cas9s are an alternative, but lack robust activity or specificity and...

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Detalles Bibliográficos
Autores principales: Schmidt, Moritz J., Gupta, Ashish, Bednarski, Christien, Gehrig-Giannini, Stefanie, Richter, Florian, Pitzler, Christian, Gamalinda, Michael, Galonska, Christina, Takeuchi, Ryo, Wang, Kui, Reiss, Caroline, Dehne, Kerstin, Lukason, Michael J., Noma, Akiko, Park-Windhol, Cindy, Allocca, Mariacarmela, Kantardzhieva, Albena, Sane, Shailendra, Kosakowska, Karolina, Cafferty, Brian, Tebbe, Jan, Spencer, Sarah J., Munzer, Scott, Cheng, Christopher J., Scaria, Abraham, Scharenberg, Andrew M., Cohnen, André, Coco, Wayne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271026/
https://www.ncbi.nlm.nih.gov/pubmed/34244505
http://dx.doi.org/10.1038/s41467-021-24454-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271026/
https://www.ncbi.nlm.nih.gov/pubmed/34244505
http://dx.doi.org/10.1038/s41467-021-24454-5

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