High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease

BACKGROUND: Genetic variants can be used to prioritize risk factors as potential therapeutic targets via Mendelian randomization (MR). An agnostic statistical framework using Bayesian model averaging (MR-BMA) can disentangle the causal role of correlated risk factors with shared genetic predictors....

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Detalles Bibliográficos
Autores principales: Zuber, Verena, Gill, Dipender, Ala-Korpela, Mika, Langenberg, Claudia, Butterworth, Adam, Bottolo, Leonardo, Burgess, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Cardiovascular Risks
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271202/
https://www.ncbi.nlm.nih.gov/pubmed/33130851
http://dx.doi.org/10.1093/ije/dyaa216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271202/
https://www.ncbi.nlm.nih.gov/pubmed/33130851
http://dx.doi.org/10.1093/ije/dyaa216

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