The Effect of Vicinal Difluorination on the Conformation and Potency of Histone Deacetylase Inhibitors

Histone deacetylase enzymes (HDACs) are potential targets for the treatment of cancer and other diseases, but it is challenging to design isoform-selective agents. In this work, we created new analogs of two established but non-selective HDAC inhibitors. We decorated the central linker chains of the...

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Detalles Bibliográficos
Autores principales: Ariawan, A. Daryl, Mansour, Flora, Richardson, Nicole, Bhadbhade, Mohan, Ho, Junming, Hunter, Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271401/
https://www.ncbi.nlm.nih.gov/pubmed/34209791
http://dx.doi.org/10.3390/molecules26133974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271401/
https://www.ncbi.nlm.nih.gov/pubmed/34209791
http://dx.doi.org/10.3390/molecules26133974

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