Immunoproteasome and Non-Covalent Inhibition: Exploration by Advanced Molecular Dynamics and Docking Methods

The selective inhibition of immunoproteasome is a valuable strategy to treat autoimmune, inflammatory diseases, and hematologic malignancies. Recently, a new series of amide derivatives as non-covalent inhibitors of the β1i subunit with K(i) values in the low/submicromolar ranges have been identifie...

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Detalles Bibliográficos
Autores principales: Culletta, Giulia, Zappalà, Maria, Ettari, Roberta, Almerico, Anna Maria, Tutone, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271555/
https://www.ncbi.nlm.nih.gov/pubmed/34279386
http://dx.doi.org/10.3390/molecules26134046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271555/
https://www.ncbi.nlm.nih.gov/pubmed/34279386
http://dx.doi.org/10.3390/molecules26134046

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