5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis

TASK channels belong to the two-pore-domain potassium (K(2P)) channels subfamily. These channels modulate cellular excitability, input resistance, and response to synaptic stimulation. TASK-channel inhibition led to membrane depolarization. TASK-3 is expressed in different cancer cell types and neur...

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Detalles Bibliográficos
Autores principales: Ramírez, David, Mejia-Gutierrez, Melissa, Insuasty, Braulio, Rinné, Susanne, Kiper, Aytug K., Platzk, Magdalena, Müller, Thomas, Decher, Niels, Quiroga, Jairo, De-la-Torre, Pedro, González, Wendy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271858/
https://www.ncbi.nlm.nih.gov/pubmed/34202296
http://dx.doi.org/10.3390/molecules26133897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271858/
https://www.ncbi.nlm.nih.gov/pubmed/34202296
http://dx.doi.org/10.3390/molecules26133897

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