Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity

New pyridine, pyrazoloyridine, and furopyridine derivatives substituted with naphthyl and thienyl moieties were designed and synthesized starting from 6-(naphthalen-2-yl)-2-oxo-4-(thiophen-2-yl)-1,2-dihydropyridine-3-carbonitrile (1). The chloro, methoxy, cholroacetoxy, imidazolyl, azide, and arylam...

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Detalles Bibliográficos
Autores principales: Abdel-Rahman, Adel A.-H., Shaban, Amira K. F., Nassar, Ibrahim F., EL-Kady, Dina S., Ismail, Nasser S. M., Mahmoud, Samy F., Awad, Hanem M., El-Sayed, Wael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272136/
https://www.ncbi.nlm.nih.gov/pubmed/34206976
http://dx.doi.org/10.3390/molecules26133923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272136/
https://www.ncbi.nlm.nih.gov/pubmed/34206976
http://dx.doi.org/10.3390/molecules26133923

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