Cargando…

Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity

New pyridine, pyrazoloyridine, and furopyridine derivatives substituted with naphthyl and thienyl moieties were designed and synthesized starting from 6-(naphthalen-2-yl)-2-oxo-4-(thiophen-2-yl)-1,2-dihydropyridine-3-carbonitrile (1). The chloro, methoxy, cholroacetoxy, imidazolyl, azide, and arylam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abdel-Rahman, Adel A.-H., Shaban, Amira K. F., Nassar, Ibrahim F., EL-Kady, Dina S., Ismail, Nasser S. M., Mahmoud, Samy F., Awad, Hanem M., El-Sayed, Wael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272136/ https://www.ncbi.nlm.nih.gov/pubmed/34206976 http://dx.doi.org/10.3390/molecules26133923

Ejemplares similares

The Development of Novel Compounds Against Malaria: Quinolines, Triazolpyridines, Pyrazolopyridines and Pyrazolopyrimidines
por: C. S. Pinheiro, Luiz, et al.
Publicado: (2019)

Synthesis and antimalarial potential of some novel quinoline-pyrazolopyridine derivatives
por: Saini, Deepika, et al.
Publicado: (2016)

Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction
por: Murlykina, Maryna V, et al.
Publicado: (2019)

Barbiturates and pyrazolopyridines for the treatment of postpartum depression—repurposing of two drug classes
por: Horwitz, Alexander B., et al.
Publicado: (2023)

Synthesis and Structure−Activity Relationships of Imidazopyridine/Pyrimidine‐ and Furopyridine‐Based Anti‐infective Agents against Trypanosomiases
por: Silva, Daniel G., et al.
Publicado: (2020)

6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist
por: Cuthbertson, Peter, et al.
Publicado: (2022)

New pyrazolopyridine and pyrazolothiazole-based compounds as anti-proliferative agents targeting c-Met kinase inhibition: design, synthesis, biological evaluation, and computational studies
por: Alamshany, Zahra M., et al.
Publicado: (2023)

Synthesis of Novel 2-Thiouracil-5-Sulfonamide Derivatives as Potent Inducers of Cell Cycle Arrest and CDK2A Inhibition Supported by Molecular Docking
por: Fatahala, Samar S., et al.
Publicado: (2021)

Comprehensive analysis of crystal structure, spectroscopic properties, quantum chemical insights, and molecular docking studies of two pyrazolopyridine compounds: potential anticancer agents
por: Polo-Cuadrado, Efraín, et al.
Publicado: (2023)

Efficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction
por: Navari, Razieh, et al.
Publicado: (2019)

Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR
por: Khattab, Reham R., et al.
Publicado: (2021)

Synthesis of a New Amino-Furopyridine-Based Compound as a Novel Fluorescent pH Sensor in Aqueous Solution
por: Zhang, Liyan, et al.
Publicado: (2021)

Design, Synthesis, Anticancer Activity and Molecular Docking of New 1,2,3-Triazole-Based Glycosides Bearing 1,3,4-Thiadiazolyl, Indolyl and Arylacetamide Scaffolds
por: Elganzory, Hussein H., et al.
Publicado: (2022)

Synthesis of new oxadiazol-phthalazinone derivatives with anti-proliferative activity; molecular docking, pro-apoptotic, and enzyme inhibition profile
por: Hekal, Mohamed H., et al.
Publicado: (2020)

The Role of Pyrazolopyridine Derivatives on Different Steps of Herpes Simplex Virus Type-1 In Vitro Replicative Cycle
por: Miranda, Milene D., et al.
Publicado: (2022)

Antiproliferative Activity of Some Newly Synthesized Substituted Nicotinamides Candidates Using Pyridine-2(1H) thione Derivatives as Synthon
por: Elnaggar, Dina H., et al.
Publicado: (2022)

Novel 1,2,3-Triazole-Coumarin Hybrid Glycosides and Their Tetrazolyl Analogues: Design, Anticancer Evaluation and Molecular Docking Targeting EGFR, VEGFR-2 and CDK-2
por: El-Sayed, Wael A., et al.
Publicado: (2022)

Urease covalently immobilized on cotton-derived nanocellulose-dialdehyde for urea detection and urea-based multicomponent synthesis of tetrahydro-pyrazolopyridines in water
por: Tamaddon, Fatemeh, et al.
Publicado: (2019)

Design, Synthesis, Characterization, and Insecticidal Bioefficacy Screening of Some New Pyridine Derivatives
por: El-Dean, Adel M. Kamal, et al.
Publicado: (2019)

Design, Synthesis and Antitumor Evaluation of Novel Pyrazolopyrimidines and Pyrazoloquinazolines
por: El-Naggar, Mohamed, et al.
Publicado: (2018)

2D-QSAR and docking study of a series of coumarin derivatives as inhibitors of CDK (anticancer activity) with an application of the molecular docking method
por: Kasmi, Rania, et al.
Publicado: (2020)

Triazoloquinoxalines-based DNA intercalators-Topo II inhibitors: design, synthesis, docking, ADMET and anti-proliferative evaluations
por: Elwan, Alaa, et al.
Publicado: (2022)

New thiazole, pyridine and pyrazole derivatives as antioxidant candidates: synthesis, DFT calculations and molecular docking study
por: Kaddouri, Yassine, et al.
Publicado: (2020)

Synthesis and Anticancer Activity of New 1-Thia-4-azaspiro[4.5]decane, Their Derived Thiazolopyrimidine and 1,3,4-Thiadiazole Thioglycosides
por: Flefel, Eman M., et al.
Publicado: (2017)

Synthesis and Cytotoxic Activity of New 1,3,4-Thiadiazole Thioglycosides and 1,2,3-Triazolyl-1,3,4-Thiadiazole N-glycosides
por: Alminderej, Fahad M., et al.
Publicado: (2019)

Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins
por: Rekha, Umapathy Vidhya, et al.
Publicado: (2020)

Synthesis, Molecular Docking and In Vitro Screening of Some Newly Synthesized Triazolopyridine, Pyridotriazine and Pyridine–Pyrazole Hybrid Derivatives
por: Flefel, Eman M., et al.
Publicado: (2018)

Synthesis, Molecular Docking, and Biofilm Formation Inhibitory Activity of Bis(Indolyl)Pyridines Analogues of the Marine Alkaloid Nortopsentin
por: Abo-Salem, Heba M., et al.
Publicado: (2021)

Novel pyrimidine Schiff bases and their selenium-containing nanoparticles as dual inhibitors of CDK1 and tubulin polymerase: design, synthesis, anti-proliferative evaluation, and molecular modelling
por: El-Kalyoubi, Samar, et al.
Publicado: (2023)

Discovery of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations
por: Nassar, Ibrahim F., et al.
Publicado: (2022)

GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents
por: Zafar, Ayesha, et al.
Publicado: (2017)

Facile One-Pot Multicomponent Synthesis of Pyrazolo-Thiazole Substituted Pyridines with Potential Anti-Proliferative Activity: Synthesis, In Vitro and In Silico Studies
por: El Azab, Islam H., et al.
Publicado: (2021)

Unveiling Natural and Semisynthetic Acylated Flavonoids: Chemistry and Biological Actions in the Context of Molecular Docking
por: El-Kersh, Dina M., et al.
Publicado: (2022)

Facile synthesis of pyrazolopyridine pharmaceuticals under mild conditions using an algin-functionalized silica-based magnetic nanocatalyst (Alg@SBA-15/Fe(3)O(4))
por: Hassanzadeh-Afruzi, Fereshte, et al.
Publicado: (2023)

The Antioxidant, Anti-Apoptotic, and Proliferative Potency of Argan Oil against Betamethasone-Induced Oxidative Renal Damage in Rats
por: Orabi, Sahar Hassan, et al.
Publicado: (2020)

Inversion kinetics of some E/Z 3-(benzylidene)-2-oxo-indoline derivatives and their in silico CDK2 docking studies
por: Mansour, Hany S., et al.
Publicado: (2021)

Synthesis, In Vitro Evaluation and Molecular Docking Studies of Novel Thiophenyl Thiazolyl-Pyridine Hybrids as Potential Anticancer Agents
por: Ashmawy, Fayza O., et al.
Publicado: (2023)

Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation
por: Hagras, Mohamed, et al.
Publicado: (2021)

Ultrasonic-induced synthesis of novel diverse arylidenes via Knoevenagel condensation reaction. Antitumor, QSAR, docking and DFT assessment
por: El-Sayed Ebead, Eman, et al.
Publicado: (2023)

Oral manifestations of COVID‐19 patients: An online survey of the Egyptian population
por: El Kady, Dina M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_u7rdt5s0p5ph7cj85a0k4d3a49