Cargando…

DNA methylation analysis reveals epimutation hotspots in patients with dilated cardiomyopathy-associated laminopathies

BACKGROUND: Mutations in LMNA, encoding lamin A/C, lead to a variety of diseases known as laminopathies including dilated cardiomyopathy (DCM) and skeletal abnormalities. Though previous studies have investigated the dysregulation of gene expression in cells from patients with DCM, the role of epige...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morival, Julien L. P., Widyastuti, Halida P., Nguyen, Cecilia H. H., Zaragoza, Michael V., Downing, Timothy L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272901/ https://www.ncbi.nlm.nih.gov/pubmed/34246298 http://dx.doi.org/10.1186/s13148-021-01127-0

Ejemplares similares

Dupuytren’s and Ledderhose Diseases in a Family with LMNA-Related Cardiomyopathy and a Novel Variant in the ASTE1 Gene
por: Zaragoza, Michael V., et al.
Publicado: (2017)

Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis
por: Widyastuti, Halida P., et al.
Publicado: (2020)

First human implant of the cardiac contractility modulation in patient with dilated cardiomyopathy–related laminopathy
por: D’Onofrio, Antonio, et al.
Publicado: (2023)

Naturally occurring canine laminopathy leading to a dilated and fibrosing cardiomyopathy in the Nova Scotia Duck Tolling Retriever
por: Bannasch, Danika L., et al.
Publicado: (2023)

Examining age-dependent DNA methylation patterns and gene expression in the male and female mouse hippocampus
por: Chinn, Carlene A., et al.
Publicado: (2021)

Stochastic modeling reveals kinetic heterogeneity in post-replication DNA methylation
por: Busto-Moner, Luis, et al.
Publicado: (2020)

Epimutations, Inheritance and Causes of Aberrant DNA Methylation in Cancer
por: Mossman, David, et al.
Publicado: (2006)

Laminopathies
por: Lattanzi, Giovanna, et al.
Publicado: (2018)

Epimutations are associated with CHROMOMETHYLASE 3-induced de novo DNA methylation
por: Wendte, Jered M, et al.
Publicado: (2019)

Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility
por: Garrido, Nicolás, et al.
Publicado: (2021)

Laminopathies: many diseases, one gene. Report of the first Italian Meeting Course on Laminopathies
por: Lattanzi, G., et al.
Publicado: (2011)

Sperm DNA Methylation Epimutation Biomarkers for Male Infertility and FSH Therapeutic Responsiveness
por: Luján, Saturnino, et al.
Publicado: (2019)

Alterations in cardiac DNA methylation in human dilated cardiomyopathy
por: Haas, Jan, et al.
Publicado: (2013)

Cardiac involvement in laminopathies
por: Boriani, Giuseppe, et al.
Publicado: (2015)

Transgenerational sperm DNA methylation epimutation developmental origins following ancestral vinclozolin exposure
por: Skinner, Michael K., et al.
Publicado: (2019)

Dilated cardiomyopathy
por: Schultheiss, Heinz-Peter, et al.
Publicado: (2019)

Defining the criteria for identifying constitutional epimutations
por: Sloane, Mathew A., et al.
Publicado: (2016)

O-4 The Italian Network for Laminopathies
por: Lattanzi, G., et al.
Publicado: (2011)

Laminopathies: clinical presentations and management
por: Hennekam, Raoul CM
Publicado: (2015)

Lipodystrophic laminopathies: Diagnostic clues
por: Guillín-Amarelle, Cristina, et al.
Publicado: (2018)

Deciphering Nuclear Mechanobiology in Laminopathy
por: Hah, Jungwon, et al.
Publicado: (2019)

Preclinical Advances of Therapies for Laminopathies
por: Benarroch, Louise, et al.
Publicado: (2021)

InterLINCing Chromatin Organization and Mechanobiology in Laminopathies
por: Shah, Parisha P., et al.
Publicado: (2023)

In situ nuclear DNA methylation in dilated cardiomyopathy: an endomyocardial biopsy study
por: Watanabe, Takatomo, et al.
Publicado: (2020)

Chromate-induced epimutations in mammalian cells.
por: Klein, Catherine B, et al.
Publicado: (2002)

Epigenetic Inheritance, Epimutation, and the Response to Selection
por: Furrow, Robert E.
Publicado: (2014)

Single-cell, locus-specific bisulfite sequencing (SLBS) for direct detection of epimutations in DNA methylation patterns
por: Gravina, Silvia, et al.
Publicado: (2015)

Advances in basic and clinical research in laminopathies
por: Politano, Luisa, et al.
Publicado: (2013)

Novel insights into the disease etiology of laminopathies
por: Ho, Chin Yee, et al.
Publicado: (2013)

Hypothalamic involvement in premature aging laminopathies
por: Cavadas, Claudia
Publicado: (2015)

Alzheimer's disease: An acquired neurodegenerative laminopathy
por: Frost, Bess
Publicado: (2016)

The Pathogenesis and Therapies of Striated Muscle Laminopathies
por: Brull, Astrid, et al.
Publicado: (2018)

Lamin A/C Mechanotransduction in Laminopathies
por: Donnaloja, Francesca, et al.
Publicado: (2020)

Reevaluating the cause of laminopathy in Alzheimer’s disease
por: Islam, Md Imamul, et al.
Publicado: (2023)

Epigenome-wide association study for pesticide (Permethrin and DEET) induced DNA methylation epimutation biomarkers for specific transgenerational disease
por: Thorson, Jennifer L. M., et al.
Publicado: (2020)

Updated clinical overview on cardiac laminopathies: an electrical and mechanical disease
por: Peretto, G., et al.
Publicado: (2018)

Hypothyroidism-induced reversible dilated cardiomyopathy
por: Rastogi, P, et al.
Publicado: (2018)

Constitutional Mosaic Epimutations - a hidden cause of cancer?
por: Lønning, Per E., et al.
Publicado: (2019)

Aberrant chromatin organization at the nexus of laminopathy disease pathways
por: Santini, Garrett T., et al.
Publicado: (2022)

Genomic Clustering of differential DNA methylated regions (epimutations) associated with the epigenetic transgenerational inheritance of disease and phenotypic variation
por: Haque, M. Muksitul, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_2ttfut20nlih7itqietpdn04si