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PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway
A growing amount of evidence has confirmed the crucial role of the prolyl isomerase PIN1 in aging and age-related diseases. However, the mechanism of PIN1 in age-related hearing loss (ARHL) remains unclear. Pathologically, ARHL is primarily due to the loss and dysfunction of hair cells (HCs) and spi...
Autores principales: | Zhang, Yanzhuo, Lv, Zhe, Liu, Yudong, Cao, Huan, Yang, Jianwang, Wang, Baoshan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273041/ https://www.ncbi.nlm.nih.gov/pubmed/34285767 http://dx.doi.org/10.1155/2021/9980444 |
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