Fine-mapping, trans-ancestral, and genomic analyses identify causal variants, cells, genes, and drug targets for type 1 diabetes

We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date (61,427 participants), yielding 78 genome-wide significant (P < 5 × 10(−8)) regions, including 36 novel. We define credible sets of T1D-associated variants and show they are enriched in immune cell-accessible ch...

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Detalles Bibliográficos
Autores principales: Robertson, Catherine C., Inshaw, Jamie R. J., Onengut-Gumuscu, Suna, Chen, Wei-Min, Santa Cruz, David Flores, Yang, Hanzhi, Cutler, Antony J., Crouch, Daniel J. M., Farber, Emily, Bridges, S. Louis, Edberg, Jeffrey C., Kimberly, Robert P., Buckner, Jane H., Deloukas, Panos, Divers, Jasmin, Dabelea, Dana, Lawrence, Jean M., Marcovina, Santica, Shah, Amy S., Greenbaum, Carla J., Atkinson, Mark A., Gregersen, Peter K., Oksenberg, Jorge R., Pociot, Flemming, Rewers, Marian J., Steck, Andrea K., Dunger, David B., Wicker, Linda S., Concannon, Patrick, Todd, John A., Rich, Stephen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273124/
https://www.ncbi.nlm.nih.gov/pubmed/34127860
http://dx.doi.org/10.1038/s41588-021-00880-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273124/
https://www.ncbi.nlm.nih.gov/pubmed/34127860
http://dx.doi.org/10.1038/s41588-021-00880-5

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