Requirement of brain interleukin33 for aquaporin4 expression in astrocytes and glymphatic drainage of abnormal tau

Defective aquaporin4 (AQP4)-mediated glymphatic drainage has been linked to tauopathy and amyloid plaque in Alzheimer’s disease. We now show that brain interleukin33 (IL33) is required for regulation of AQP4 expression in astrocytes, especially those at neuron-facing membrane domain (n-AQP4). First,...

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Detalles Bibliográficos
Autores principales: Wu, Jean, Carlock, Colin, Shim, Junbo, Moreno-Gonzalez, Ines, Glass, William, Ross, April, Barichello, Tatiana, Quevedo, Joao, Lou, Yahuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273186/
https://www.ncbi.nlm.nih.gov/pubmed/33432186
http://dx.doi.org/10.1038/s41380-020-00992-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273186/
https://www.ncbi.nlm.nih.gov/pubmed/33432186
http://dx.doi.org/10.1038/s41380-020-00992-0

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