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Etoposide, an anticancer drug involved in therapy-related secondary leukemia: Enzymes at play

Etoposide is a semi-synthetic glycoside derivative of podophyllotoxin, also known as VP-16. It is a widely used anticancer medicine in clinics. Unfortunately, high doses or long-term etoposide treatment can induce therapy-related leukemia. The mechanism by which etoposide induces secondary hematopoi...

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Detalles Bibliográficos
Autores principales: Zhang, Wenchao, Gou, Panhong, Dupret, Jean-Marie, Chomienne, Christine, Rodrigues-Lima, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273223/
https://www.ncbi.nlm.nih.gov/pubmed/34243013
http://dx.doi.org/10.1016/j.tranon.2021.101169