Cargando…

Functional Domains and Evolutionary History of the PMEL and GPNMB Family Proteins

The ancient paralogs premelanosome protein (PMEL) and glycoprotein nonmetastatic melanoma protein B (GPNMB) have independently emerged as intriguing disease loci in recent years. Both proteins possess common functional domains and variants that cause a shared spectrum of overlapping phenotypes and d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chrystal, Paul W., Footz, Tim, Hodges, Elizabeth D., Jensen, Justin A., Walter, Michael A., Allison, W. Ted
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273697/ https://www.ncbi.nlm.nih.gov/pubmed/34207849 http://dx.doi.org/10.3390/molecules26123529

Ejemplares similares

Disrupting the Repeat Domain of Premelanosome Protein (PMEL) Produces Dysamyloidosis and Dystrophic Ocular Pigment Reflective of Pigmentary Glaucoma
por: Hodges, Elizabeth D., et al.
Publicado: (2023)

Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils
por: Leonhardt, Ralf M., et al.
Publicado: (2013)

Repeat domain-associated O-glycans govern PMEL fibrillar sheet architecture
por: Graham, Morven, et al.
Publicado: (2019)

Identification of critical amino acid residues in the regulatory N-terminal domain of PMEL
por: Mitchell, Susan M., et al.
Publicado: (2021)

Mutations in or near the Transmembrane Domain Alter PMEL Amyloid Formation from Functional to Pathogenic
por: Watt, Brenda, et al.
Publicado: (2011)

The Role of GPNMB in Inflammation
por: Saade, Marina, et al.
Publicado: (2021)

Proprotein Convertases Process Pmel17 during Secretion
por: Leonhardt, Ralf M., et al.
Publicado: (2011)

PMEL Amyloid Fibril Formation: The Bright Steps of Pigmentation
por: Bissig, Christin, et al.
Publicado: (2016)

Human Antibody V(H) Domains Targeting GPNMB and VCAM-1 as Candidate Therapeutics for Cancers
por: Chu, Xiaojie, et al.
Publicado: (2023)

Cell-surface GPNMB and induction of stemness
por: Okita, Yukari, et al.
Publicado: (2018)

Melanosomal formation of PMEL core amyloid is driven by aromatic residues
por: Hee, Jia Shee, et al.
Publicado: (2017)

ADAM10 Releases a Soluble Form of the GPNMB/Osteoactivin Extracellular Domain with Angiogenic Properties
por: Rose, April A. N., et al.
Publicado: (2010)

Elevated circulating Gpnmb levels are associated with hyperthyroidism
por: Lin, Jiayang, et al.
Publicado: (2020)

Endoplasmic Reticulum Export, Subcellular Distribution, and Fibril Formation by Pmel17 Require an Intact N-terminal Domain Junction
por: Leonhardt, Ralf M., et al.
Publicado: (2010)

A missense mutation in PMEL17 is associated with the Silver coat color in the horse
por: Brunberg, Emma, et al.
Publicado: (2006)

Length variations within the Merle retrotransposon of canine PMEL: correlating genotype with phenotype
por: Murphy, Sarah C., et al.
Publicado: (2018)

Nonsense mutation in PMEL is associated with yellowish plumage colour phenotype in Japanese quail
por: Ishishita, Satoshi, et al.
Publicado: (2018)

Anti-inflammatory role of Gpnmb in adipose tissue of mice
por: Nickl, Bernadette, et al.
Publicado: (2021)

Evolutionary history of the TBP-domain superfamily
por: Brindefalk, Björn, et al.
Publicado: (2013)

Modulating functional amyloid formation via alternative splicing of the premelanosomal protein PMEL17
por: Dean, Dexter N., et al.
Publicado: (2020)

gp100/pmel17 and tyrosinase encode multiple epitopes recognized by Th1-type CD4+T cells
por: Kierstead, L S, et al.
Publicado: (2001)

The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis
por: Tanaka, Hirotaka, et al.
Publicado: (2012)

Endothelin-1 enhances the melanogenesis via MITF-GPNMB pathway
por: Zhang, Ping, et al.
Publicado: (2013)

Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
por: Gillett, Drew A., et al.
Publicado: (2023)

Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation
por: Hellström, Anders R., et al.
Publicado: (2011)

Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL
por: Burgoyne, Thomas, et al.
Publicado: (2015)

sPmel17 Secreted by Ultraviolet B-Exposed Melanocytes Alters the Intercellular Adhesion of Keratinocytes
por: Hu, Shuang-Hai, et al.
Publicado: (2022)

PMEL as a Prognostic Biomarker and Negatively Associated With Immune Infiltration in Skin Cutaneous Melanoma (SKCM)
por: Zhang, Shuguang, et al.
Publicado: (2021)

Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis
por: Katayama, Akihiro, et al.
Publicado: (2015)

GPNMB methylation: a new marker of potentially carcinogenic colon lesions
por: Ashktorab, Hassan, et al.
Publicado: (2018)

Investigating a downstream gene of Gpnmb using the systems genetics method
por: Lu, Ye, et al.
Publicado: (2019)

GPNMB contributes to a vicious circle for chronic obstructive pulmonary disease
por: Zhang, Xi-Juan, et al.
Publicado: (2020)

Prognostic values of GPNMB identified by mining TCGA database and STAD microenvironment
por: Yao, Kunhou, et al.
Publicado: (2020)

GPNMB is expressed in human epidermal keratinocytes but disappears in the vitiligo lesional skin
por: Biswas, Kazal Boron, et al.
Publicado: (2020)

Evolutionary history of the vertebrate Piwi gene family
por: Gutierrez, Javier, et al.
Publicado: (2021)

Evolutionary History of the Globin Gene Family in Annelids
por: Belato, Flávia A, et al.
Publicado: (2020)

Identification of the Genomic Insertion Site of Pmel-1 TCR α and β Transgenes by Next-Generation Sequencing
por: Ji, Yun, et al.
Publicado: (2014)

PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin
por: Miao, Xiao, et al.
Publicado: (2018)

Indication of Premelanosome Protein (PMEL) Expression Outside of Pigmented Bovine Skin Suggests Functions Beyond Eumelanogenesis
por: Knaust, Jacqueline, et al.
Publicado: (2020)

GPNMB expression identifies TSC1/2/mTOR‐associated and MiT family translocation‐driven renal neoplasms
por: Salles, Daniela C, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ccjkmsjqgh936cfq78vpdntols