Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-β-Lactamases

[Image: see text] In an attempt to exploit the hydrolytic mechanism by which β-lactamases degrade cephalosporins, we designed and synthesized a series of novel cephalosporin prodrugs aimed at delivering thiol-based inhibitors of metallo-β-lactamases (MBLs) in a spatiotemporally controlled fashion. W...

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Detalles Bibliográficos
Autores principales: Tehrani, Kamaleddin H. M. E., Wade, Nicola, Mashayekhi, Vida, Brüchle, Nora C., Jespers, Willem, Voskuil, Koen, Pesce, Diego, van Haren, Matthijs J., van Westen, Gerard J. P., Martin, Nathaniel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273888/
https://www.ncbi.nlm.nih.gov/pubmed/34182755
http://dx.doi.org/10.1021/acs.jmedchem.1c00362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273888/
https://www.ncbi.nlm.nih.gov/pubmed/34182755
http://dx.doi.org/10.1021/acs.jmedchem.1c00362

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