Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant

[Image: see text] Human isocitrate dehydrogenase (IDH1) and its cancer-associated variant (IDH1 R132H) are rendered electroactive through coconfinement with a rapid NADP(H) recycling enzyme (ferredoxin-NADP(+) reductase) in nanopores formed within an indium tin oxide electrode. Efficient coupling to...

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Detalles Bibliográficos
Autores principales: Herold, Ryan A., Reinbold, Raphael, Megarity, Clare F., Abboud, Martine I., Schofield, Christopher J., Armstrong, Fraser A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273889/
https://www.ncbi.nlm.nih.gov/pubmed/34170697
http://dx.doi.org/10.1021/acs.jpclett.1c01517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273889/
https://www.ncbi.nlm.nih.gov/pubmed/34170697
http://dx.doi.org/10.1021/acs.jpclett.1c01517

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