Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin

BACKGROUND: Although the major anticancer effect of metformin involves AMPK-dependent or AMPK-independent mTORC1 inhibition, the mechanisms of action are still not fully understood. METHODS: To investigate the molecular mechanisms underlying the effect of metformin on the mTORC1 inhibition, MTT assa...

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Detalles Bibliográficos
Autores principales: Jang, Se-Kyeong, Hong, Sung-Eun, Lee, Da-Hee, Kim, Ji-Young, Kim, Ji Yea, Ye, Sang-Kyu, Hong, Jungil, Park, In-Chul, Jin, Hyeon-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273940/
https://www.ncbi.nlm.nih.gov/pubmed/34253170
http://dx.doi.org/10.1186/s12885-021-08346-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273940/
https://www.ncbi.nlm.nih.gov/pubmed/34253170
http://dx.doi.org/10.1186/s12885-021-08346-x

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