Alpha1-antitrypsin counteracts heme-induced endothelial cell inflammatory activation, autophagy dysfunction and death

Free heme toxicity in the vascular endothelium is critical for the pathogenesis of hemolytic disorders including sickle cell disease. In the current study, it is demonstrated that human alpha1-antitrypsin (A1AT), a serine protease inhibitor with high binding-affinity for heme, rescues endothelial ce...

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Detalles Bibliográficos
Autores principales: Madyaningrana, Kukuh, Vijayan, Vijith, Nikolin, Christoph, Aljabri, Abid, Tumpara, Srinu, Korenbaum, Elena, Shah, Harshit, Stankov, Metodi, Fuchs, Heiko, Janciauskiene, Sabina, Immenschuh, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274343/
https://www.ncbi.nlm.nih.gov/pubmed/34246063
http://dx.doi.org/10.1016/j.redox.2021.102060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274343/
https://www.ncbi.nlm.nih.gov/pubmed/34246063
http://dx.doi.org/10.1016/j.redox.2021.102060

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