Cargando…

The interplay of Rac1 activity, ubiquitination and GDI binding and its consequences for endothelial cell spreading

Signaling by the Rho GTPase Rac1 is key to the regulation of cytoskeletal dynamics, cell spreading and adhesion. It is widely accepted that the inactive form of Rac1 is bound by Rho GDI, which prevents Rac1 activation and Rac1-effector interactions. In addition, GDI-bound Rac1 is protected from prot...

Descripción completa

Detalles Bibliográficos
Autores principales: Majolée, Jisca, Podieh, Fabienne, Hordijk, Peter L., Kovačević, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274835/
https://www.ncbi.nlm.nih.gov/pubmed/34252134
http://dx.doi.org/10.1371/journal.pone.0254386