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A novel high-throughput screen for identifying lipids that stabilise membrane proteins in detergent based solution

Membrane proteins have a range of crucial biological functions and are the target of about 60% of all prescribed drugs. For most studies, they need to be extracted out of the lipid-bilayer, e.g. by detergent solubilisation, leading to the loss of native lipids, which may disturb important protein-li...

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Detalles Bibliográficos
Autores principales: Cecchetti, Cristina, Strauss, Jannik, Stohrer, Claudia, Naylor, Claire, Pryor, Edward, Hobbs, Jeanette, Tanley, Simon, Goldman, Adrian, Byrne, Bernadette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274869/
https://www.ncbi.nlm.nih.gov/pubmed/34252116
http://dx.doi.org/10.1371/journal.pone.0254118