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Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dimensional drug-channel interaction model

State-dependent sodium channel blockers are often prescribed to treat cardiac arrhythmias, but many sodium channel blockers are known to have pro-arrhythmic side effects. While the anti and proarrhythmic potential of a sodium channel blocker is thought to depend on the characteristics of its rate-de...

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Detalles Bibliográficos
Autores principales: Docken, Steffen S., Clancy, Colleen E., Lewis, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274935/
https://www.ncbi.nlm.nih.gov/pubmed/34185778
http://dx.doi.org/10.1371/journal.pcbi.1009145